Testicular cancer

Testicular Cancer


Facts about Testicular Cancer

  • Testicular cancer is not common; a man’s lifetime chance of getting it is about 1 in 263. The risk of dying from this cancer is about 1 in 5,000.
  • The American Cancer Society’s estimates for testicular cancer in the United States for 2016 are: About 8,720 new cases of testicular cancer will be diagnosed. About 380 men will die of testicular cancer.

Research scope in Testicular Cancer

  • Melatonin has an apoptotic effect on cryopreserved mouse testicular cells….more
  • Identification of lymphovascular invasion (LVI) in testicular germ cell tumors (GCTs) is a challenging yet important aspect of cancer staging that can alter therapeutic management….more
  • microRNAs (miRs)-371-3 are suggested to be novel biomarkers of germ cell tumors (GCTs), but their specificity is unresolved….more
  • Mutated MTOR represents a potential target for novel targeted therapies for refractory testicular germ cell tumors (tGCTs)...more
  • Cisplatin causes male infertility but the exact mechanism have not been clarified...more
  • Gemcitabine, oxaliplatin, and paclitaxel (GOP) is the current option of choice in cisplatin-refractory patients. Novel targeted agents failed to improve treatment outcome so far...more
  • PD-1/PD-L1 pathway could be a novel therapeutic target in Testicular germ cell tumors (TGCTs)..more

Treatment for Testicular Cancer

  • Testicular cancer. Clinical practice guidelines in oncology...more
  • Holoxan when combined with Vepesid and Adriblastin as third-choice therapy one could achieve further improvement...more
  • Salvage Therapy for Patients With Germ Cell Tumor....more
  • NCCN clinical practice guidelines in oncology: testicular cancer..more
  • Concurrent use of curcumin during chemotherapy in testis cancer should be avoided due to the inhibitory effect of curcumin on bleomycin-induced apoptosis….more

Prevention of Testicular Cancer

  • Prevention strategies for testicular and penile cancer: an integrative review...more
  • Effective cholesterol control may lower the risk of cancer...more
  • Prevention strategies for testicular and penile cancer: an integrative review..more
  • Meta-analysis showed an inverse association between high maternal BMI and testicular cancer risk of borderline statistical significance...more
  • Curcumin induces apoptosis and inhibits proliferation in NTera-2 cells via the inhibition of AP-2γ-mediated downstream cell survival signaling pathways, useful in the treatment of human malignant testicular germ cells...more

Risk factors for Testicular Cancer

  • High dairy product intake, in particular high intake of cheese (odds ratio [OR] = 1.87; 95% confidence interval [CI] 1.22-2.86; p-trend < 0.001), is associated with an elevated risk of testicular cancer in Canadian males...more
  • Exposure to cigarette smoking in utero increases the risk of testicular cancer...more
  • Testicular Microlithiasis (TM) is significantly associated with risk of testicular cancer....more
  • Boys with isolated cryptorchidism are three times more likely to develop testicular cancer. ...more
  • Occupational hazards experienced by firefighters may increase the risk of testicular cancer….more
  • Those using cannabis on at least a weekly basis had two and a half times greater odds of developing a non-seminoma testicular germ cell tumours (TGCT) compared those who never used cannabis (OR: 2.59, 95 % CI 1.60–4.19)....more
  • The study support a relationship between subfertility and increased risk of testicular cancer ..more
  • HDAC inhibitor-driven LTR12 activation represents a generally applicable means to induce proapoptotic genes in human cancer cells...more
  • Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C and is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation...more

Systematic reviews

  • Positive association of adult height and testicular germ-cell tumour (TGCT) ...more
  • Circulating concentrations of IGF-I and IGFBP-3 are associated with an increased risk of common cancers...more
  • Treatment of testicular germ-cell cancer: a cochrane evidence-based systematic review…more
  • Cryptorchidism, inguinal hernia and twinning, and tentative evidence that birth weight and gestational age, are associated with risk of testicular cancer...more
  • Radiotherapy or chemotherapy for clinical stage IIA and IIB seminoma: a systematic review and meta-analysis of patient outcomes....more

Treatment with Medicinal Herbs

  • Rue (Ruta graveolens) – Dose – 0-1.5 g herb as emmenagogue; 0.5-1 g herb, several x/day; 1-2 tsp herb/cup water 1-3 x/day; 1-2 g dried herb 
  • Vervain (Verbena officinalis) – Dose – 1.5 -4 g to 3x/day; 4.5-9 g, as often happens, is the Chinese dose; 1 tsp herb/cup water 1-4 x/day; 2-4 g dry herb, or in tea, 3x/day; infusion of 5-20 g herb/liter water, take 2-4 g up to 3x/day  
  • White Lily, Madonna Lily (Lilium candidum) – Dose – Apply a thick paste, made from fresh or cooked “onion” = lily bulbs

Reference: Handbook of Medicinal Herbs (2006)


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