Skin cancer

Skin cancer

Skin cancer

Facts about Skin Cancer

  • Skin cancer is the most common cancer.
  • About 5.4 million basal and squamous cell skin cancers are diagnosed each year. 
  • (These are found in about 3.3 million Americans; some people have more than one.) Melanoma, the most deadly type of skin cancer, will account for about 76,380 cases of skin cancer in 2016.

Research scope in Skin Cancer

  • miR21/GRHL3/D3 axis that reduces TH in the tumor microenvironment and has potential to be targeted as a therapeutic approach to BCC…..more
  • Sox9 is a β-catenin downstream transcription factor and is positively involved in SCC development....more
  • Synergy between α-Mangostin and sorafenib, with mechanistic actions that convert a known safe natural product to a candidate combinatorial therapeutic agent…..more
  • Targeting the PIP3-binding pocket of P-Rex1 with a new generation of cancer chemotherapeutic agents….more
  • DETS is a powerful antioxidant, having anticancer efficacy comparable with that of resveratrol, and is a potential candidate to be explored by in vivo studies and in-depth mechanistic evaluation...more
  • FRA1 promotes cancer growth through AKT, and enhances cancer cell migration through JNK/c-Jun, pinpointing FRA1 as a key integrator of JNK and AKT signaling pathways and a potential therapeutic target for squamous cell carcinoma of the skin (cSCC) and head and neck (HNSCC)....more
  • 734THIF nanoparticles are characterized by improved physicochemical properties, increased water solubility, and enhanced skin penetration, and these may have potential use in the future as a topical delivery formulation for the treatment of skin diseases..more

Treatment for Skin Cancer

  • Mohs micrographic surgery with MART-1 immunostain is an effective treatment of melanoma....more
  • Electrochemotherapy may represent a new locoregional treatment for selected patients with superficial angiosarcomas.more
  • Fumaric acid ester (FAEs) could be an alternative and safe treatment in patients with therapy-refractory cutaneous lupus erythematosus (CLE)....more
  • Sunitinib effective and safe in the treatment of metastatic renal cell carcinoma..more
  • Evidence supports the use of topical imiquimod as monotherapy for superficial BCC and topical fluorouracil as monotherapy for superficial BCC and SCC in situ..more

Prevention of Skin Cancer

  • Green leafy vegetables may help prevent development of subsequent SCCs of the skin among people with previous skin cancer ..more
  • The risk of SCC was slightly decreased in regular users of any NSAIDs (adj. OR: 0.89, 95% CI: 0.82-0.97), with the strongest risk reduction observed in current users of coxibs (adj. OR: 0.77, 95% CI: 0.62-0.95). These findings provide evidence that patients predisposed to NMSC might benefit from chemoprevention with NSAIDs…more
  • Peel consumption, the major source of dietary d-limonene, is not uncommon and may have a potential protective effect in relation to skin SCC..more
  • Rosiglitazone may reduce the risk of NMSC, but further confirmation is required....more
  • Study indicated a critical role for folate in skin and the potential to protect sun exposed skin by effective topical delivery as a strategy for cancer prevention....more

Risk factors for Skin Cancer

  • Study suggest an inverse association between vitamin D blood levels and cutaneous melanoma (CM) thickness at diagnosis. Further research is needed...more
  • High density of freckles, skin colour, eye colour, and hair colour are significantly associated with the risk of skin cancer….more
  • Exposure to high levels of sunlight in childhood is a strong determinant of melanoma risk, but sun exposure in adulthood also plays a role...more
  • Organ transplant recipients (OTRs) have an increased risk of developing skin cancer, especially epithelial tumours….more
  • Voriconazole should be used carefully for durations >6-9 months, particularly among patients with risk factors for skin cancer….more
  • Smoking increases the risk of cutaneous squamous cell carcinoma ...more
  • rs78378222 C allele is a potent risk factor for overall cancer….more
  • Alcohol Intake is Associated with Increased Risk of Squamous Cell Carcinoma of the Skin….more
  • Aspirin intake was associated with a reduced risk of developing skin cancer.  ...more

Systematic reviews

  • An association between short PLTL and reduced risk for cutaneous melanoma....more
  • HIV/AIDS is associated with an increased risk of non-melanoma skin cancer in both men and women patients...more
  • XRCC3 T241M polymorphism was associated with risk of melanoma…more
  • Consumption of high levels of n-3 PUFAs were inversely associated with melanoma...more
  • MTHFR 1298C allele is associated with increased skin cancer risk...more
  • Critical appraisal of clinical practice guidelines for adaptation in the evidence-based guideline “prevention of skin cancer”...more

Treatment with Medicinal Herbs

  • Sorrel (Rumex acetosa) – Dose – Food farmacy but don’t overdo it
  • Safflower (Carthamus tinctorius) – Dose – 1 g flower in tea to 3 x/day; 1-2 tsp fresh flower; 2-3 g dry flower; 3 g dry flower; 15 ml alcohol/15 ml water 
  • Poke Root (Phytolacca americana) – Dose – 0.2-1 g dry root/day; 60-300 mg root; 0.06-0.3 g powered root; 0.1-0.5 liquid root extract; 0.1-0.5 ml liquid root extract (1:1 in 45% ethanol) 3x/day 

Reference: Handbook of Medicinal Herbs (2006)


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