Rheumatoid arthritis

Rheumatoid Arthritis

Rheumatoid arthritis

Facts about Rheumatoid Arthritis

  • About 1.3 million people in the U.S., or 1% of adults, have rheumatoid arthritis
  • RA costs $5,763 (in year 2000 dollars) per person who has the disease every year. Annual medication costs can reach $15,000 to $20,000 per patient treated with a biologic agent.
  • Out of every 100,000 people, 41 are diagnosed with RA every year. About 1.3 million Americans have RA.

Research scope in Rheumatoid Arthritis

  • APL1 therapy could help to ameliorate the pathogenic Th17/Treg balance in RA patients….more
  • MMP-3 may be regarded as an early marker for joint destruction in RA.more
  • SP600125 is of potential use in promoting the regeneration of bone and cartilage in OA and RA…..more
  • (p40)2-Fc can be a potential therapeutic approach for autoimmune arthritis....more
  • The serum COMP level has the potential to be used as a biological marker for differentiating between patients with RA and healthy individuals….more
  • New SHP-1 molecular targets have been suggested like SIRP-α, PIPKIγ, and RIP-1 that may prove to be the focal point for the development of therapeutic strategies….more

Treatment for Rheumatoid Arthritis

  • Tocilizumab (TCZ) monotherapy or in combination with non-biologic DMARDs resulted in a significant effect on the endpoints in moderate to severe RA in Saudi Arabia….more
  • Curcumin might help identify a new therapeutic pathway against hyperplasia of the synovial fibroblasts in RA...more
  • Findings indicate that Iyengar yoga (IY) is a feasible complementary approach for young people with RA, although larger clinical trials are needed to demonstrate safety and efficacy....more
  • At least in the short term, physical and, particularly, exercise therapy produce a favorable improvement in the functional status of the rheumatoid hand...more
  • Effectiveness and safety of dietary interventions for rheumatoid arthritis: a systematic review of randomized controlled trials...more
  • The study showed that fluoride therapy was well tolerated and increased vertebral bone mass in patients with RA...more

Prevention of Rheumatoid Arthritis

  • Consumption of both cooked vegetables and olive oil was inversely and independently associated with risk of RA...more
  • Moderate consumption of alcohol is associated with reduced risk of rheumatoid arthritis...more
  • Dietary intake of long-chain n-3 PUFAs may play a role in aetiology of RA….more
  • Early rheumatoid arthritis: strategies for prevention and management...more
  • Oral administration of apple condensed tannins delays rheumatoid arthritis development....more

Risk factors for Rheumatoid Arthritis

  • Coffee consumption (OR = 2.18; 1.07-4.42, for > 10 versus 0 cups per day), ever use of oral contraceptives (OR = 1.65; 1.06-2.57) and having a first-degree relative with schizophrenia (OR = 4.18; 1.54-11.3) appeared more strongly associated with risk of anti-CCP-positive RA….more
  • Patients of a younger age and with frequently recurrent chronic osteomyelitis (COM) had a greater increase in RA risk...more
  • Exposure to tobacco smoke, or some factor or cluster of factors associated with smoking, may trigger the production of rheumatoid factors....more
  • There is an association between the MTHFR C677T polymorphism and susceptibility for the development of RA….more
  • Obesity is associated with a modest risk for developing RA..more
  • Meta-analysis of 215,757 participants suggests that low vitamin D intake is associated with an elevated risk of RA development....more
  • Exposure to breast-feeding after the first pregnancy is associated with a significant increase in risk for RA development...more

Systematic reviews

  • Depression is more common in patients with rheumatoid arthritis...more
  • Physical activity in rheumatoid arthritis: a systematic review….more
  • Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review…more
  • Yoga for rheumatic diseases: a systematic review...more
  • Evidence is not convincing enough to suggest that tai chi is an effective treatment for RA....more
  • An increase in body mass index can contribute to a higher risk for rheumatoid arthritis development..more

Treatment with Medicinal Herbs

  • Yellow Jessamine (Gelsemium sempervirens) – Dose – As per the recommendation from homeopathic 
  • Yarrow, Milfoil (Achillea millefolium) – Dose – 1-2 tsp herb/cup water 3-4 x/day; 4.5 g herb; 2-4 tbsp herb; 2-4 ml liquid herb extract (1:1 in 25% ethanol) 
  • Wood Sage (Teucrium scorodonia) – Dose – 2 tsp (~2.6 g) herb/cup; 2-4 ml liquid herb extract; herb poulticed topically 

Reference: Handbook of Medicinal Herbs (2006)

Herbals

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