Renal cancer

Renal Cancer

Kidney cancer

Facts about Renal Cancer

  • Renal parenchymal cancer is the most common kidney cancer, accounting for approximately 80–90 per cent of all primary kidney cancer
  • Approximately 273,000 new cases of kidney cancer are diagnosed worldwide each year
  • Patients with advanced RCC have five-year survival rates of approximately 11-12 percent
  • The most recent estimates of incidence of kidney cancer suggest that there are approximately 102,000 new
    cases each year in Europe, while approximately 45,000 people in Europe are likely to die from kidney cancer
    each year

Research scope in Renal Cancer

  • A little is known about potential racial differences in tumor biology of Clear Cell Renal Cell Carcinoma (ccRCC)…more
  • Xp11.2 translocation/transcription factor enhancer 3 (TFE3) fusion gene associated with renal cell carcinoma (Xp11.2 translocation RCC)…more
  • Lower plasma levels of adiponectin, and higher levels of RBP4 and NAMPT, are strongly correlated with RCC, indicating that these adipokines could be used as biomarkers for RCC…more
  • Study suggests that nuclear Lyn is a potential therapeutic target for clear cell renal cell carcinoma (ccRCC)…more
  • Few reports have provided functional analyses of miR-26a or miR-26b in renal cell carcinoma (RCC)…more
  • In vitro and in vivo results demonstrate that miR-155 functions as a tumor-promoting miRNA by targeting E2F2 in clear cell renal cell carcinoma (ccRCC)…more

Prevention of Renal Cancer

  • Moderate alcohol consumption was associated with a decreased risk of renal cancer…more
  • Overall, an increase in consumption of 1 cup of coffee per day was associated with a 3% reduced risk of cancers (RR, 0.97; 95% CI, 0.96-0.98)…more
  • Meta-analysis provides strong support for an inverse relation of physical activity to renal cancer risk…more
  • High consumption of fruits and vegetables might be associated with reduced risk of RCC…more
  • Statins appear to be protective against the development of renal cell carcinoma…more
  • Running and walking may reduce incident kidney cancer risk independent of its other known risk factors…more
  • There is an inverse relation of physical activity to renal cancer risk…more

Treatment for Renal Cancer

  • Review of guidelines on the treatment of metastatic renal cell carcinoma…more
  • Clinical practice guidelines for the treatment of metastatic renal cell carcinoma: today and tomorrow…more
  • Kidney cancer: current and novel treatment options….more
  • First-line treatment in the management of advanced renal cell carcinoma: systematic review and network meta-analysis…more
  • Systematic review and meta-analysis of target terapies for the treatment of metastatic renal cancer…more

Risk factors for Renal Cancer

  • Acetaminophen and non-aspirin NSAIDs are associated with a significant risk of developing kidney cancer...more
  • Meta-analysis suggests that a high Cd exposure may be a risk factor for renal cancer in occupational population…more
  • Hypertension is a risk factor for renal cancer among both blacks and whites…more
  • Hysterectomy for benign indications was significantly associated with renal cell carcinoma…more
  • Obesity, both early and later in life, is associated with an increased risk of renal cancer…more
  • Smoking is a risk factor for progression of Chronic kidney disease (CKD)….more

Systematic reviews

  1. Risk factors for adult renal cell carcinoma: a systematic review and implications for prevention...more
  2. Management of Renal Masses and Localized Renal Cancer..more
  3. Effect of sirolimus on malignancy and survival after kidney transplantation…more
  4. Systematic review and meta-analysis of target terapies for the treatment of metastatic renal cancer…more
  5. Local treatments for metastases of renal cell carcinoma: a systematic review…more
  6. A Systematic Review of Sequencing and Combinations of Systemic Therapy in Metastatic Renal Cancer…more
  7. Prevention and Early Detection of Urologic Cancers: A Mini-Reviewmore
  8. Links between cancer and weight, nutrition and physical activity…more
  9. Fruits and Vegetables Intake and Risk of Bladder Cancer…more

Treatment with Medicinal Herbs

  • Agrimony (Agrimonia eupatoria) – Dose 3 -6 g herb; 1 tsp herb/cup water; 1-3 ml extract (1:1 in 25% ethanol) 3x/day; 2-4 ml liquid herb extract; 1-4 ml tincture (1:5) in 45% alcohol 3x/day
  • Anise (Pimpinella anisum) – Dose, 1 tsp crushed seed/cup water 3 x/day; 3 g seed, or 300 mg seed oil/day; 0.5-1 g seed in tea, 3 x/day ; 0.5-3 g fruits; 20 g fruit in alcohol or water; 0.5-1 tsp tincture up to 3 x/day; 0.05-0.2 ml fruit EO; 0.3-1 ml anise water; 0.3-1.2 ml anise spirit

Reference: Handbook of Medicinal Herbs (2006)


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