Psychosis

Psychosis

Brain

Facts about Psychosis

  • Psychosis affects males and females equally
  • Approximately 3 percent of people will experience an episode of psychosis in their lifetimes

Research scope in Psychosis

  • Selective 5-HT(2A) receptor antagonists is a new drug development target for psychosis prevention….more
  • Glutamatergic therapies may be useful in psychosis prevention.more
  • There is a plausible role of early life exposure to metals in the cause of psychosis....more
  • It is possible to identify individuals with a high likelihood of onset of psychosis within a brief follow-up period...more
  • It is unknown how the presence and persistence of Psychotic experiences (PEs) during early adulthood affects cognition and brain function.more
  • The long-term risk of suicide after a first episode of psychosis is unknown.…more
  • The long-term consequences of synthetic cannabinoid use on preexisting psychotic disorders are unclearmore

Treatment for Psychosis

  • CBT-informed treatment is associated with a reduced risk of transition to psychosis at 6, 12 and 18-24 months, and reduced symptoms at 12 months....more
  • Early detection and secondary prevention of psychosis: facts and visions….more
  • Aerobic exercise and yoga improve neurocognitive function in women with early psychosis....more
  • Early intervention in psychosis for young people reduces the risk of suicide…more
  • Adding yoga intervention to standard pharmacological treatment is feasible and may be beneficial even in the early and acute stage of psychosis...more
  • New treatments for psychotic disorders....more
  • Efficacy and safety of pharmacological and psychological interventions…more

Prevention of Psychosis

  • Long-chain omega-3 PUFAs reduce the risk of progression to psychotic disorder...more
  • A step towards indicated prevention of schizophrenia...more
  • Cost-effectiveness of preventing first-episode psychosis in ultra-high-risk subjects...more
  • Early interventions to prevent psychosis: systematic review and meta-analysis...more
  • Therapeutic potential of popular music in psychosis: a meta-analysis...more

Risk factors for Psychosis

  • There is now reasonable evidence from longitudinal studies that regular cannabis use predicts an increased risk of schizophrenia and of reporting psychotic symptoms...more
  • Early childhood trauma increases the risk for positive psychotic symptoms...more
  • Daily tobacco use is associated with increased risk of psychosis...more
  • Individuals with Coeliac disease (CD) may be at increased risk of non-affective psychosis...more
  • Ginseng may be associated with acute and significant psychiatric disturbances...more
  • Anti-cholinergic drugs should be regarded as a potential risk factor for psychosis in Alzheimer’s disease...more
  • cannabis use exacerbates psychosis...more
  • Individuals with autism spectrum disorder (ASD) are at increased risk for nonaffective psychotic disorder (NAPD) or bipolar disorder (BD)...more
  • Structural brain abnormalities that have been commonly reported in adults with psychosis are present early in life in youth with PS symptoms and are not due to medication effects...more
  • Excessive khat chewing seemed to be related to psychotic symptoms...more

Systematic reviews

  • A Systematic Review of the Effect of Early Interventions for Psychosis on the Usage of Inpatient Services...more
  • Psychotic major depression in older people: a systematic review...more
  • Are antipsychotics or antidepressants needed for psychotic depression? A systematic review and meta-analysis of trials comparing antidepressant or antipsychotic monotherapy with combination treatment…more
  • Antipsychotic efficacy in psychosis with co-morbid cannabis misuse: A systematic review...more
  • Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis...more

Treatment with Medicinal Herbs

  • Fenugreek (Trigonella foenum-graecum) – Dose 1 tbsp mashed seed/8 oz water, up to 3x/day as gargle; 1-6 g seed 3 x/day; 5-90 g seed/day; 0.25-0.5 cup seed; 6-12 g dry seed; 50 g powdered seed with 0.25 liter water
  • Fig (Ficus carica) – Dose – Food farmacy; 30 g fig syrup; steep 2 fruits in wine or booze overnight, then eat on an empty stomach for whooping cough; boil 3 sun-dried leaves for 15 minutes in 300 g water for diabetes 
  • Agrimony (Agrimonia eupatoria) – Dose 3 -6 g herb; 1 tsp herb/cup water; 1-3 ml extract (1:1 in 25% ethanol) 3x/day; 2-4 ml liquid herb extract; 1-4 ml tincture (1:5) in 45% alcohol 3x/day

Reference: Handbook of Medicinal Herbs (2006)

Herbals

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