Parkinson disease (PD)

Parkinson Disease (PD) 

Brain

Facts about Parkinson Disease (PD)

  • Parkinson disease (PD) is the second most common neurodegenerative disorder in the United States.
  • Parkinson’s disease is named after Dr James Parkinson (1755-1824), the doctor that first identified the condition.
  • The main symptoms of Parkinson’s disease are tremor, slowness of movement (bradykinesia) and muscle stiffness or rigidity.
  • The risk of developing Parkinson’s disease increases with age.  Symptoms usually occur after the age of 50.
  • Around 1 in 20 people are diagnosed under the age of 40 years.

Research scope in Parkinson Disease (PD)

  • NADPH oxidase plays important role in the initiation/promotion of neuronal degeneration by increasing ROS in close proximity to protein machineries, including those for ZNRF1 and EGFR, thereby promoting neuronal degeneration….more
  • Inhibition of LCN2 expression or activity may be useful in protecting the nigrostriatal dopaminergic projection in Parkinson’s disease (PD)....more
  • Study findings warrant further exploration of globus pallidus externa (GPe) as a target for interventions for Parkinson’s disease….more
  • DNAJC13 mutations have been suggested to cause Parkinson’s disease (PD)...more
  • SLC1A2 rs3794087 may decrease the risk for PD in a Chinese….more
  • Opicapone (OPC) is a new COMT inhibitor that significantly decreased COMT activity and increased systemic exposure to levodopa in PD patients with motor fluctuations…..more

Treatment for Parkinson Disease (PD)

  • Curcumin: a potential neuroprotective agent in Parkinson’s disease…more
  • Current approaches to the treatment of Parkinson’s disease....more
  • Latest treatment options for Alzheimer’s disease, Parkinson’s disease dementia and dementia with Lewy bodies....more
  • Efficacy and safety of acupuncture for idiopathic Parkinson’s disease….more
  • Dance as an intervention for people with Parkinson’s disease….more

Prevention of Parkinson Disease (PD)

  • Full truncal vagotomy is associated with a decreased risk for subsequent PD, suggesting that the vagal nerve may be critically involved in the pathogenesis of PD….more
  • Serum urate may exert protective effects against Parkinson’s disease (PD) through its antioxidant capacities…more
  • High vitamin D status provides protection against Parkinson’s disease…more
  • Calcium channel blockers (CCBs) use was associated with a Significantly decreased risk of PD compared with non-CCB use....more
  • Caffeine may represent a promising therapeutic tool in PD...more

Risk factors for Parkinson Disease (PD)

  • Pesticide exposure might represent a candidate for environmental factors involved in Parkinson’s disease….more
  • Central obesity may be associated with higher PD risk among never smokers….more
  • Among patients aged ≥55 years presenting to inpatient/ED settings with trauma, TBI is associated with a 44% increased risk of developing PD over 5 to 7 years....more
  • Weak association between alcohol drinking and PD riske….more
  • Study showed an increased risk of developing PD in patients with migraine….more
  • CC haplotype in DMT1 gene is a possible risk factor for PD in this Han Chinese population....more
  • The strongest risk factors associated with later PD diagnosis are having a family history of PD or tremor, a history of constipation, and lack of smoking history….more

Systematic reviews

  • CoQ10 supplementation does not slow functional decline nor provide any symptomatic benefit for patients with Parkinson’s disease....more
  • Living in a rural area, drinking well water, farming, and exposure to pesticides may be a risk factor for developing PD….more
  • There is strong epidemiological evidence that smokers and coffee drinkers have a lower risk of Parkinson’s disease….more
  • Cholinesterase inhibitor (ChIs) are effective in the treatment of cognitive impairment in patients with PD, but do not affect risk of falls…more
  • Tai Chi performed with medication resulted in promising gains in mobility and balance, and it was safe and popular among PD patients at an early stage of the disease….more

Treatment with Medicinal Herbs

  • Camu-Camu (Myrciaria dubia) – Dose – 3-4 fruits providing 300-400 mg vitamin C
  • Chrysanthemum, Mum (Chrysanthemum x morifolium Ramt) – Dose – 4.5 – 12 g flower  
  • Cowitch, Cowhage, Velvetbean (Mucuna pruriens) – Dose – 0.6-4 g honey or syrup with stinging hairs for worms, for 2-3 days in the a.m.; 1.5 -2.5 g powered seed 
  • Faba Bean (Vicia faba) – Dose – 1 once calculated that it take a proud of faba beans or a couple ounces of sprouts, to give a physiological dose of L-dopa  

Reference: Handbook of Medicinal Herbs (2006)

Herbals

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