Ovary cancer

Ovary cancer

Ovary cancer

Facts about Ovary Cancer

  • Unfortunately, 77% of ovarian cancer cases are diagnosed in an advanced stage.
  • The sooner ovarian cancer can be correctly diagnosed, the greater a woman’s chances are of surviving it. 
  • Ovarian cancer is diagnosed annually in nearly a quarter of a million women globally, and is responsible for 140,000 deaths each year.
  • Unlike some other cancers, developing and developed nations are similarly affected by the disease. 
  • In the US, approximately 25,000 women will be diagnosed with ovarian cancer each year. 

Research scope in Ovary Cancer

  • MTHFR polymorphic variant T may contribute to increased risk in East Asians....more
  • Study suggests the potential role of dietary lycopene against the risk of ovarian cancer among postmenopausal women, which provides opportunity for developments in the prevention of ovarian cancer.more
  • Genetic analysis of CCCO is important to find the right target(s) and better therapeutic approaches. Because of its rarity, international collaboration is necessary to conduct randomized clinical trials for Clear-cell carcinoma of the ovary (CCCO)..more
  • PAX8 has a cell specific role in governing proliferation and migration in nontransformed ovarian surface epithelium cells compared to the oviductal cells, but its reduction in serous cancer cell lines provides a common mechanism for reducing cell survival...more
  • B7-H1 and B7-H4 is a negative prognostic marker for EOC and a potential immunotherapeutic target for patients with EOC...more
  • Radiolabelled Zn(II)Pc 2 might be a promising nuclear imaging and PDT agent for colon, lung, pancreas and ovary tumours....more
  • TWIST2/Vimentin co-expression might be a novel indicator with prognostic potential in epithelial ovarian cancer (EOC)...more

Treatment for Ovary Cancer

  • Treatment guidelines in ovarian cancer...more
  • Treatment options in recurrent ovarian cancer: latest evidence and clinical potential...more
  • Non-epithelial ovarian cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up...more
  • First-line treatment of advanced ovarian cancer: current research and perspectives...more
  • Second-line treatment of ovarian cancer...more
  • Advanced (>second) line chemotherapy in the treatment of patients with recurrent epithelial ovarian cancer....more
  • Effectiveness of third-line chemotherapy in recurrent ovarian cancer patients..more
  • Sorafenib fails to achieve sufficient objective response or sustained disease stabilization as third-line treatment for EOC...more

Prevention of Ovary Cancer

  • The study supports a protective association between paracetamol use and ovarian cancer, and provides evidence for a dose effect..more
  • Levonorgestrel-releasing intrauterine system (LNG-IUS) use associated with decreased risk for both invasive and borderline ovarian tumors….more
  • Oral contraceptives could be used as a means to prevent ovarian cancer in carriers of BRCA1 and BRCA2 mutations..more
  • These data suggest that regular use of acetaminophen, but not aspirin, may be associated with lower risk of ovarian cancer....more
  • Regular tea consumption is associated with a reduced risk of ovarian cancer ..more
  • Curcumin could significantly inhibit the growth of ovary cancer cells...more

Risk factors for Ovary Cancer

  • High intakes of lactose and dairy products, particularly milk, are associated with an increased risk of serous ovarian cancer...more
  • Breastfeeding and a longer duration of breastfeeding are associated with lower risks of  epithelial ovarian cancer (EOC)...more
  • Breastfeeding for 8 to 10 months may be most effective for reducing the risk of ovarian cancer....more
  • High intakes of dairy foods and lactose may increase the risk of ovarian cancer...more
  • Androstenedione may be associated with increased ovarian cancer risk....more

Systematic reviews

  • Screening for ovarian cancer: a systematic review...more
  • Study showed the potential therapeutic effects of metformin on survival outcomes of ovarian cancer and ovarian cancer prevention...more
  • Dietary intake and ovarian cancer risk: a systematic review…more
  • Cost Effectiveness of Chemotherapeutic Agents and Targeted Biologics in Ovarian Cancer...more
  • Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis...more
  • Ovarian cancer survivors’ quality of life: a systematic review...more

Treatment with Medicinal Herbs

  • ST. John’s Wart (Hypericum perforatum) – Dose – 2-4 g dry herb (0.2-1 hypericin)/day; 2-5 g dry herb/day; 2-4 ml liquid herb extract; 2-4 g dry shoot, or in tea, 3x/day
  • Wild Indigo (Baptisia tinctoria) – Dose – 2-5 ml root tincture; 0.5-1 g root 3x/day  
  • Congorosa (Maytenus ilicifolia Marf) – Dose – 100-400 ml decoction/tea (2-5%); 5-20 g powered leaf; 25-100 ml tincture 

Reference: Handbook of Medicinal Herbs (2006)


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