Osteoporosis

Osteoporosis

Rheumatoid arthritis

Facts about Osteoporosis

  • Osteoporosis is a disease in which the bones become weak and are more likely to break. People with osteoporosis most often break bones in the hip, spine, and wrist.
  • At least 1 in 3 women and 1 in 5 men will suffer from an osteoporotic fracture during their lifetime.
  • Over 80% of all fractures in people 50+ are caused by osteoporosis.
  • Osteoporosis causes 70-90% of 30,000 hip fractures annually.
  • Twenty-eight per cent of women and 37% of men who suffer a hip fracture will die within the following year.

Research scope in Osteoporosis

  • The benefits of osteoporosis therapy are compromised by low adherence, thus requiring a better understanding of its barriers and unmet needs….more
  • Bisphosphonates (BPs) inhibit bone resorption and are frequently used to treat osteoporosis, bone metastasis, and other conditions that result in bone fragility. However, numerous studies have reported that BPs are closely related to the development of osteonecrosis of the jaw (BRONJ), which is an intractable disease...more
  • ESR1 polymorphisms at rs2234693 and rs9340799 may be associated with osteoporosis (OP), and could be used as markers to screen those with high risks to postmenopausal OP in Chinese women....more
  • Study suggest that oral supplementation of a novel neoflavonoid dalsissooal isolated from heartwood of Dalbergia sissoo Roxb. exhibited bone anabolic action by improving structural property of bone, promoting new bone formation and reducing bone turnover rate in post-menopausal model for osteoporosis with no uterine hyperplasia...more
  • Tumor necrosis factor α inhibitors (TNFi) are the major class of biologic drug used for the treatment of Rheumatoid arthritis (RA). Their effects on inflammation and disease control are well established, but this is not true also for bone metabolism, especially for key factors as parathyroid hormone and Wnt pathway...more

Treatment for Osteoporosis

  • The study shows that the multiaxial expandable pedicle screw is a safe and practical technique for patients with osteoporosis and various spinal diseases and adds a valuable tool to the armamentarium of spinal instrumentation...more
  • Oral daily ibandronate prevents bone loss in early postmenopausal women without osteoporosis.more
  • A vitamin D supplement of 800 IU per day in combination with calcium may decrease the incidence of non-vertebral fractures, especially in persons in the older age groups having low-baseline vitamin D status and low calcium intake and showing good compliance...more
  • Clinician’s Guide to Prevention and Treatment of Osteoporosis...more
  • Meta-analysis reveals that soy isoflavone supplements significantly increase bone mineral density and decrease the bone resorption marker urinary DPD...more

Prevention of Osteoporosis

  • The VDR BsmI polymorphism may have a protective role against the development of osteoporosis...more
  • Exercise can significantly enhance bone strength at loaded sites in children but not in adults...more
  • In HF patients, it is important to carefully assess osteoporosis and take measures to reduce the risk of osteoporotic fractures...more
  • Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis...more
  • Halofuginone (presently FDA-approved for treatment of scleroderma)0 prevents estrogen-deficient osteoporosis in mice...more

Risk factors for Osteoporosis

  • Older patients with schizophrenia are at risk for low bone density. Cigarette smoking and alcohol abuse are associated with low bone density in patients with schizophrenia..more
  • Study suggests that in addition to alcohol, other lifestyle factors–such as tobacco use, nutrition, weight-bearing exercise, increased body weight, and hormone replacement therapy–affect bone development and osteoporosis risk in women...more
  • Osteoporosis risk is high in patients with chronic obstructive pulmonary disease...more
  • Accumulation of cadmium (Cd), an extremely toxic metal, can cause renal failure, decreased vitamin D synthesis, and consequently osteoporosis...more

Systematic reviews

  • Treatments for osteoporosis with established vertebral and nonvertebral fracture efficacy reduce mortality in older, frailer individuals with osteoporosis who are at high risk of fracture...more
  • Meta-analyses of therapies for postmenopausal osteoporosis….more
  • Metabolic syndrome (MetS) is a risk factor for developing osteoporosis in men….more
  • Magnesium (Mg) seems to be a risk factor for OP among the postmenopausal women...more
  • Proton-pump inhibitors (PPIs) use modestly increased the risk of hip, spine, and any-site fracture…more

Treatment with Medicinal Herbs

  • Horsetail (Equisetum arvense) – Dose – 2-4 tbsp (2-4 g) fresh herb; 1-4 g herb/cup water; 4.5 g herb: 22 ml alcohol/23 ml water 
  • Hedge Hyssop (Gratiola officinalis) – Dose – 0.3 g/cup herb tea; 0.15-0.3 g powered herb or decoction thereof
  • Wolfberry (Lycium chinense) – Dose – 9-15 g fruit /day in tea; sip tea through the day for pertusis 
  • Ground Ivy (Glechoma hederacea)– Dose – 2-4 g dry herb, or in tea, 1-3 x/day; 2-4 ml liquid herbal extract (1:1 in 25% ethanol)

Reference: Handbook of Medicinal Herbs (2006)

Herbals

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