Facts about Migraine

  • Migraine is the third most common disease in the world (behind dental caries and tension-type headache) with an estimated global prevalence of 14.7% (that’s around 1 in 7 people).
  • Migraine is more prevalent than diabetes, epilepsy and asthma combined.
  • Chronic migraine affects approximately 2% of the world population.
  • Migraine affects three-times as many women as men, with this higher rate being most likely hormonally-driven.
  • Migraine often starts at puberty and most affects those aged between 35 and 45 years, but it can trouble much younger people including children.

Research scope in Migraine

  • Neuromodulation is a promising, novel approach for the treatment of primary headache disorders. Neuromodulation offers a new dimension in the treatment that is both easily reversible and tends to be very well tolerated…..more
  • CGRP-RAs are viable options for the acute treatment of migraine.more
  • Previous studies have demonstrated the presence of active TrPs in women with migraine reproducing their headache attacks. No study has investigated if these TrPs can alter muscle function in the cervical spine in migraine….more
  • Although probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PMmore
  • Onabotulintoxin A (BontA) is an efficacious preventive treatment for chronic migraine, though the specific mechanism of action is still under discussion...more
  • The therapeutic potential of magnesium, coenzyme Q(10), riboflavin, and vitamin B(12) can be cautiously inferred in the treatment of migraine....more
  • There is a high prevalence of migraine headaches in patients with allergic rhinitis (AR) compared with those without AR…more

Treatment for Migraine

  • Gabapentin is an effective prophylactic agent for patients with migraine....more
  • Melatonin may be effective in treating several primary headache disorders, particularly cluster headache and migraine…..more
  • An 8-week study, 10 mg/d flunarizine is more effective than 50 mg/d topiramate for Chronic migraine (CM) prophylaxis…..more
  • Greater occipital nerve block (GON) block could be an effective symptomatic treatment for prolonged or persistent migraine aura…more
  • TEV-48125 is good for the preventive treatment of chronic migraine….more

Prevention of Migraine

  • High-dose riboflavin treatment is efficacious in migraine prophylaxis…more
  • The study demonstrated that simvastatin plus vitamin D is effective for prevention of headache in adults with episodic migraine…more
  • Preventive treatment in migraine and the new US guidelines….more
  • Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults...more
  • Zonisamide is effective and well tolerated for migraine prevention in patients refractory to topiramate...more

Risk factors for Migraine

  • Obesity is a stronger risk factor for transformed migraine than for chronic tension-type headache….more
  • C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, may act as a genetic susceptibility factor for migraine...more
  • Iron Deficiency Anemia Is Associated with Menstrual Migraine…more
  • There are strong indications regarding the association between Helicobacter pylori (HP) and migraine...more
  • Childhood abuse and IPV are associated with increased odds of migraine in pregnant women….more
  • The prevalence rate of migraine is significantly higher in acute cerebral infarction (ACI) patients than non-ACI subjects in the population of elderly Chinese...more

Systematic reviews

  • Triptans are effective in the Acute Treatment of Migraine: A Systematic Review and Network Meta-Analysis..more
  • Cognitive behavioural therapy for the management of headaches and migraines in adults..more
  • Risk of ischaemic stroke in people with migraine: systematic review…more
  • Botulinum Toxin A for Prophylactic Treatment of Migraine and Tension Headaches in Adults
    A Meta-analysis..
  • Essential oils used in aromatherapy: A systemic review....more
  • Prevalence of headache and migraine in children and adolescents….more

Treatment with Medicinal Herbs

  • Devil’s Claw (Harpagophytum procumbens) – Dose – 1 tsp chopped root/2 cups water, 1 g dry root: 5 ml alcohol/5 ml water; 6-12 ml liquid extract (1: 2)/day; 15-30 ml tincture (1:5)/day 
  • Woodruff (Galium odoratum) – Dose – 2 tsp (1.8 g) shoots/glass water; 1 g drug/day 
  • Wooly Digitalis (Digitalis lanata) – Dose – Prescription only; Rapid digitalization dose 0.75 digoxin; maintenance dose 0.25-0.75 mg/day orl human
  • Yellow Sweet Clover (Melilotus officinalis) – Dose – Pour 150 ml boiling water over 1-2 tsp finely chopped herb; 2 tsp (4.2 g) herb cold tea/day; parenterally 1-7.5 mg coumarin; 1 mg/kg coumarin, equivalent to ca. 10 ml/day liquid extract (1:2)

Reference: Handbook of Medicinal Herbs (2006)


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