Liver cancer

Liver cancer

Liver Cancer

Facts about Liver Cancer

  • Liver cancer incidence has more than tripled since 1980.
  • Liver cancer death rates have generally been increasing since 1980; from 2003 to 2012, rates increased by 2.7% per year.
  • The average age at diagnosis of liver cancer is 63. More than 95% of people diagnosed with liver cancer are 45 years of age or older. About 3% are between 35 and 44 years of age and about 2% are younger than 35.

Research scope in Liver Cancer

  • HNF1A-AS1-miR-30b axis is a key regulator in hepatocarcinogenesis, which may be promising biomarkers and therapeutic targets in the future….more
  • Apelin receptor Apelin/APJ may be a potential anticancer therapeutic target.more
  • FcγRIIIa resided in KCs, and it contributes to the inhibition of the growth of liver tumor cells....more
  • There are several interventional therapies that improve the prognosis and increase the survival rate of early-stage hepatocellular carcinoma (early-stage HCC), but it is uncertain about whether one is superior to others...more
  • SLC44A5 is involved in HCC carcinogenesis and progression in HCC, indicating that SLC44A5 may be a molecular target in cancer therapy...more
  • RTKN2 may act as an oncogene and inhibition of RTKN2 may be part of a novel therapeutic strategy for targeted HCC therapy...more
  • BRD4-E2F2-cell cycle regulation as a novel molecular circuit in liver cancer and provide a therapeutic strategy and innovative insights for liver cancer therapies....more
  • Study reveals the involvement of SIRT1 in HCC metastasis and provide a rationale for exploring therapeutic targets against the SIRT1/PGC-1α axis...more
  • SLAMF3 overexpression in cancerous cells could represent a potential therapeutic strategy to improve the drugs sensibility of resistant cells and thus control the therapeutic failure in HCC patients...more

Treatment for Liver Cancer

  • Hepatocellular carcinoma-cause, treatment and metastasis….more
  • Treatment of hepatocellular carcinoma: a systematic review.more
  • Imaging Techniques for the Diagnosis of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis....more
  • Current Management of Hepatocellular Carcinoma...more
  • Treatment of hepatocellular carcinoma: beyond international guidelines...more

Prevention of Liver Cancer

  • Meta-analysis suggest that an increased consumption of coffee may reduce the risk of liver cancer...more
  • Vaccination against hepatitis B (or protection against hepatits C), which reduces prevalence of carriers, would reduce the potency of the aflatoxins in vaccinated populations and reduce liver cancer risk...more
  • Vitamin E intake, either from diet or supplements, may reduce the risk of liver cancer...more
  • Aspirin use was associated with a reduced intrahepatic cholangiocarcinoma (ICC) risk in men (HR, 0.64; 95% CI, 0.42-0.98) but not women (HR, 1.34; 95% CI, 0.89-2.01; P(interaction) = 0.01)...more
  • Meta-analysis suggests that statin is associated with a significant risk reduction of liver cancer when taken daily for cardiovascular event prevention...more
  • Meta-analysis suggest that a higher fish intake is associated with reduced risk of liver cancer...more
  • Estrogen-mediated inhibition of IL-6 production by Kupffer cells (KCs) reduces liver cancer risk in females, and these findings may be used to prevent HCC in males...more
  • Higher fish intake is associated with reduced risk of liver cancer...more
  • Preventive effects of green tea intake on the risk for liver cancer...more

Risk factors for Liver Cancer

  • One alcoholic drink per day (~12 g/day) may be associated with a 1.1 times higher liver cancer risk...more
  • Exercise may reduce risk for lung and hepatic cancer and prevent an ethanol-induced increase in risk for hepatic cancer by enhancing activity of antioxidant and phase II enzymes...more
  • Hepatic steatosis is a risk factor for HCC in patients with chronic HCV infection...more
  • Chronic HBV-infected patients with high hepatic AKR1B10 expression had an increased risk of HCC development...more
  • Anti-diabetic medications (ADMs) may modify the risk of hepatocellular cancer (HCC) in patients with DM...more
Liver cancer

Systematic reviews

  • Screening for Hepatocellular Cancer in Chronic Liver Disease: A Systematic Review...more
  • Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma...more
  • Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies…more
  • Meta-Analysis of Randomized Controlled Trials Assessing the Effect of Sorafenib in Advanced Hepatocellular Carcinoma...more
  • A meta-analysis of adjuvant therapy after potentially curative treatment for hepatocellular carcinoma...more

Treatment with Medicinal Herbs

  • Echinacea, Purple Coneflower – Dose – 1-2 tsp fresh root; 3 g dry root; 3 g dry root: 15 ml alcohol/15 mg water; 2 tsp root/cup water to 3x/day; 1-2 g root as tea 3x/day 
  • Thyme (Thymus vulgaris) – Dose – 2-4 tbsp fresh leaf; 3-6 g dry leaf; 4.5 g dry leaf: 22 ml alcohol/23 ml water; 1 tsp herb/cup water 1-3 x/day; 1-2 g herb/cup several x/day; 3 tsp (~7.2 g) herb in hot tea 
  • Poison Hemlock (Conium maculatum) – Dose – Maximum 300 mg; standard 100 mg; not to exceed 1500 mg/day 

Reference: Handbook of Medicinal Herbs (2006)


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