Facts about Hyperthyroidism

  • More than 27 million Americans have some sort of thyroid disease. About 13 million have no idea they suffer from a thyroid imbalance.
  • Typically, women are more prone to thyroid issues than men.
  • The thyroid secretes three important hormones—thyroxine (T4), triiodothyronine (T3), and calcitonin.  
  • Important nutrients for the thyroid are iodine, tyrosine, B vitamins, vitamin A, selenium, zinc, and the essential fatty acids to name a few.

Research scope in Hyperthyroidism

  • Resistin may serve as a link between thyroid dysfunction and insulin resistance…..more
  • Preventive interventions to diminish the risk of AITD are few, not always feasible, and probably of limited efficacy..more
  • Whether radioactive iodine treatment of Graves’ disease (GD) during pregnancy will increase pregnancy loss and affect fetal development is still a matter of concern....more
  • Despite the availability of thyroid hormone replacement for more than a century, there are still substantial challenges in practice and opportunities to improve treatment outcomes….more
  • Currently, no test can accurately predict the development of azotemia after treatment of hyperthyroidism. Serum cystatin C concentrations (sCysC) might be less influenced by changes in body muscle mass and so better indicate the presence of concurrent chronic kidney disease (CKD) in hyperthyroidism...more
  • The influence of antithyroid drugs (ATDs) on the therapeutic efficacy of radioactive iodine in hyperthyroidism is still controversial….more
  • Hyperthyroidism can induce molecular changes associated with degeneration of the hippocampus….more

Prevention of Hyperthyroidism

  • Drinking herbal teas, especially chamomile, protects from thyroid cancer as well as other benign thyroid diseases…more
  • Moderate alcohol consumption is associated with a considerable reduction in the risk of Graves’ disease with hyperthyroidism–irrespective of age and gender.more
  • Stress may provoke Graves hyperthyroidism but not Hashimoto thyroiditis. Estrogen use have been linked to a lower prevalence of Graves disease....more
  • Iodine intake is an important component of preventive health care to reduce the prevalence of thyroid disorders..more
  • Thyroid dysfunction is an important causative etiology of menstrual abnormalities. Assessment of thyroid function should be done in all patients with menstrual disorders to avoid unnecessary interventions like curettage and hysterectomy...more

Risk factors for Hyperthyroidism

  • Smoking is a risk factor for Graves’ hyperthyroidism in women….more
  • Positivity for microsome antibody at the beginning of interferon-alpha therapy for chronic hepatitis C is a risk factor for thyroid dysfunction...more
  • Nitrate may play a role in the etiology of thyroid cancer and thyroid disease...more
  • Graves’ disease maybe an extrahepatic manifestation of acute HBV infection. Antiviral therapy is likely to be beneficial for this condition as without severe thyrotoxicosis....more
  • Dronedarone and Amiodarone Induce Dyslipidemia and Thyroid Dysfunction....more

Secondary complications

  • Subclinical hyperthyroidism was associated with an increased risk of hip and other fractures, particularly among those with TSH levels of less than 0.10 mIU/L and those with endogenous subclinical hyperthyroidism...more
  • A low serum thyrotropin concentration is associated with a >5-fold higher likelihood for the presence of atrial fibrillation with no significant difference between subclinical and overt hyperthyroidism...more
  • Hyperthyroidism is an independent risk factor of developing adhesive capsulitis...more
  • Hypothyroidism (HT) was found highly prevalent in patient with clinical coronary heart disease, mainly in females, and was associated with several cardiovascular risk factors...more
  • Subclinical hyperthyroidism in the elderly increases the risk of dementia and Alzheimer’s disease...more
  • Patients with hyperthyroidism are at increased risk of cancer, especially thyroid cancer...more
  • Male sex, increasing age, ischemic heart disease, congestive heart failure, and heart valve disease are associated with an increased risk of atrial fibrillation or flutter in patients with hyperthyroidism...more
  • Endogenous subclinical hyperthyroidism is associated with increased risks of total, CHD mortality, and incident AF, with highest risks of CHD mortality and AF when thyrotropin level is lower than 0.10 mIU/L...more

Systematic reviews

  • T2DM patients are more likely to have subclinical hypothyroidism (SCH) when compared with healthy population and SCH may be associated with increased diabetic complications...more
  • The study found hypothyroidism associated with increased all-cause mortality as well as cardiac death and/or hospitalization in patients with HF..more
  • SCH may be associated with an increased risk of the metabolic syndrome (MS), which could be attributed to the increased risk of metabolic components…more
  • The study suggest that other strategies for the management of Graves’ disease, such as radioiodine, should be considered more frequently as first-line therapy….more
  • Long term lithium treated patients should be monitored for the development of thyroid dysfunction...more

Treatment with Medicinal Herbs

  • Motherwort (Leonurus cardiaca) – Dose – 1.5 – 6 g/day; 2-4 g in tea 3x/day; 2-4 mg liquid herb extract; 10-15 drops tincture up to 3x/day 
  • Rehmannia, Chiese Foxglove (Rehmannnia glutinosa) – Dose – 9-30 g powdered; 2-6 g root/day; 15 g root/ ml red wine; 4-12 ml fluid root extract  

Reference: Handbook of Medicinal Herbs (2006)


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