HIV/AIDS

HIV/AIDS

AIDS

Facts about HIV/AIDS

  • HIV/AIDS is world’s most significant public health challenges, particularly in low- and middle-income countries.
  • HIV continues to be a major global public health issue, having claimed more than 34 million lives so far.

Research scope in HIV/AIDS

  • When to start antiretroviral therapy for HIV infection on the basis of the CD4+ count has been controversial. Initiating when CD4+ more than 500 cells per cubic millimeter showed more benefitsmore 
  • “Shock and kill” promising for HIV eradication which includes histone deacetylase inhibitors (HDACI), histone methyltransferases (HMT), DNA methyltransferase inhibitors (DNMTI), and protein kinase C (PKC) activators...more
  • Patients with HIV and tuberculosis in eastern Europe have a risk of death nearly four-times higher than that in patients from western Europe and Latin America due to lack of drug susceptibilitymore
  • New therapeutic area: APOBEC1 (A1) proteins from lagomorphs and rodents have deaminase-dependent restriction activity against HIV-1, whereas human A1 exerts a negligible effect...more

Treatment for HIV/AIDS

  • HIV patients are at more risk of bone fracture, more…
  • Coformulated Tenofovir and 3TC/FTC are the backbone therapy for human immunodeficiency virus (HIV) postexposure prophylaxis (PEP), meta-analysis of 15 studies, more…
  • Cistus incanus extract found highly potent against HIV, more…
  • World Health Organization Guidelines on Postexposure Prophylaxis for HIV: Recommendations for a Public Health Approach, more…

Prevention of HIV/AIDS

  • New Zealand has a good international HIV prevention record among, gay and bisexual men (GBM)…more
  • There is need for the involvement of the stakeholders in bridging the gap between knowledge of and attitude towards prevention of MTCT of HIV/AIDS among health care workers in the rural areas…more

Risk factors for HIV/AIDS

  • HPV infection, linked to anal warts and anal cancer, is common among men who have sex with men (MSM), especially among those HIV positives…more
  • In HIV patients, higher CD4 levels are associated with significantly reduced mortality rates in the 15 to 50 age group but this association was not seen in the >50 age group…more
  • A quarter million new infant acquires HIV infections from mother in the each year….more
  • Fever may directly stimulate HIV-1 replication, in a process involving Hsp90 and facilitation of Tat-mediated LTR activity…more

Systematic reviews

  • Systematic review of the efficacy of antiretroviral therapies for reducing the risk of mother-to-child transmission of HIV infection…more
  • Comparative effectiveness of tenofovir in treatment-naïve HIV-infected patients: systematic review and meta-analysis...more
  • Dual Therapy Treatment Strategies for the Management of Patients Infected with HIV: A Systematic Review of Current Evidence in ARV-Naive or ARV-Experienced, Virologically Suppressed Patients…more
  • Effect of treating co-infections on HIV-1 viral load: a systematic review…more
  • Efavirenz-Based Regimens in Antiretroviral-Naive HIV-Infected Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials…more
  • Economic impact of HIV/AIDS: a systematic review in five European countries…more

Treatment with Medicinal Herbs

  • Daffodil (Narcissus tazetta)

Reference: Handbook of Medicinal Herbs (2006)

Herbals

Discovery of key component of HIV yields new drug target

Scientists from the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge and University College London have discovered an essential feature of HIV that the virus uses to infect cells whilst avoiding detection by the immune system. This discovery, published in Nature, presents a new drug target and the opportunity to re-evaluate existing treatments for HIV to improve their efficacy. More at: https://www.sciencedaily.com

 

HN3New find brings HIV vaccine closer to reality

A team of scientists has identified immunological profiles of people who make powerful HIV antibodies, paving the way for development of a vaccine. People living with HIV who naturally produce broadly neutralizing antibodies (bNAbs) that may help suppress the virus have different immunological profiles than people who do not, researchers report. While bNAbs cannot completely clear HIV infections in people who have already acquired the virus, many scientists believe a successful preventive HIV vaccine must induce bNAbs. More at: http://www.deccanchronicle.com/

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