Hepatitis C virus

Hepatitis C virus

Virus 1

Facts about Hepatitis C virus

  • Hepatitis C is a liver disease caused by the hepatitis C virus: the virus can cause both acute and chronic hepatitis infection, ranging in severity from a mild illness lasting a few weeks to a serious, lifelong illness.
  • Globally, between 130–150 million people globally have chronic hepatitis C infection.
  • A significant number of those who are chronically infected will develop liver cirrhosis or liver cancer.
  • Approximately 700 000 people die each year from hepatitis C-related liver diseases 

Research scope in Hepatitis C virus

  • A recent study performed on animals shows that a new quinoline derivative GNS-396 as antiviral inhibit HCV infection in a dose-dependent manner without cytotoxic effect.
  • Mechanism of action of ribavirin being poorly understood.
  • HCV infection is still underdiagnosed, picking up on it early, sufficient treatment and follow up may reduce healthcare costs in the long run by significant measures.
  • Blocking PDK activity might have therapeutic benefits against HCV replication.

Treatment for Hepatitis C virus

  • Statin drug use is beneficial in mitigating the risk of liver disease progression for HIV/HCV co-infected patients without advanced liver disease.
  • Coumarins inhibit viral replication through an IFN-mediated anti-viral response. 
  • Daclatasvir plus PR are the most effective in SVR12 and SVR24, but caused an increased AEs profile (headache and insomnia). 
  • Sofosbuvir is safe and effective in the treatment of hepatitis C virus genotype 1, 2, 3, or 4 infections. 

Complications of Hepatitis C virus

  • Patients with HCV exhibit a significantly increased risk of developing PD.
  • Chronic HCV infection may be an independent risk factor for thyroid disturbance.
  • Older age, poor standards of living, HCV genotype 4, smoking, and null genotypes of GST were the risk factors associated significantly with the development of HCC.
  • HCV infection was associated with an increase in NHL risk

Risk factors for Hepatitis C virus

  • Hepatitis C Virus Infection is associated with an increased risk of Deep Vein Thrombosis.
  • Tattooing is associated with HCV infection.
  • T2DM is associated with increased susceptibility to HCV infection.
  • Schistosomiasis seems to be a possible risk factor for acquiring HCV.

Systematic reviews

  • Alcohol has no effect on hepatitis C virus replication…more
  • A Systematic Review of Race and Ethnicity in Hepatitis C Clinical Trial Enrollment…more
  • Prevention of Hepatitis C by Screening and Treatment in U.S. Prisons…more
  • Sexual transmission of hepatitis C virus and prevention with intramuscular immunoglobulin…more

References

Risk scope

  • World J Hepatol. 2016 Jul 28;8(21):902-14
  • Liver Int. 2016 Jul 30. doi: 10.1111/liv.13212. [Epub ahead of print]
  • J Infect Public Health. 2016 Jul 30. pii: S1876-0341(16)30064-8. doi: 10.1016/j.jiph.2016.05.008. [Epub ahead of print]
  • Sci Rep. 2016 Jul 29;6:30846

Risk factors

  • Medicine (Baltimore). 2015 Sep;94(38)
  • Hepatology. 2013 Jun;57(6):2117-23
  • Sci Rep. 2013 Oct 18;3:2981
  • Saudi J Gastroenterol. 1997 May;3(2):74-7

Secondary complications

  • Medicine (Baltimore). 2015 Sep;94(38)
  • Hepatology. 2013 Jun;57(6):2117-23
  • Sci Rep. 2013 Oct 18;3:2981
  • Saudi J Gastroenterol. 1997 May;3(2):74-7

Treatment

  • AIDS. 2016 Aug 3. [Epub ahead of print]
  • Org Biomol Chem. 2013 Mar 21;11(11)
  • Medicine (Baltimore). 2016 Mar;95(9)
  • Int J Clin Pharm. 2015 Oct;37(5):698-708

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