Head & Neck cancer

Head & Neck cancer


Facts about Head & Neck Cancer

  • Head and neck cancer accounts for about 3% of all cancers in the United States
  • Cigarette smoking increases your risk of head and neck cancer by 15 times compared to a non-smoker
  • People who use both tobacco and alcohol are at greater risk than people who use them alone
  • Environmental factors such as exposure to sunlight can cause skin cancer, melanoma including cancers of the lips
  • Squamous cell cancer of the head and neck is common worldwide (4% of all cancers in the United States; 5% in the United Kingdom)

Research scope in Head & Neck Cancer

  • Reirradiation therapy (re-RT) is the only potentially curative treatment option for patients with locally recurrent head and neck cancer (HNC)…more
  • Hhead and neck cancer (HNSCC) is the sixth most common tumor entity worldwide therapy options remain limited leading to 5-year survival rates of only 50 %…more
  • PGC-1α-TFAM mitochondrial pathway may be associated with malignant potential in human oral SCC, and could be an attractive therapeutic target…more
  • Better understanding of sphere-forming cells (SFC) can help identify novel druggable cancer targets…more
  • Liprin-α1 is a novel regulator of the tumor cell and can help to develop new anti-cancer drugs…more
  • Triptolide (TPL) is a potential candidate among novel chemotherapeutic agents or adjuvants for modulating tumor-associated macrophages in a tumor microenvironment of HNSCC…more
  • There may be a potential association between GERD and risk of HNCs, which however merits further studies to confirm the causal relationship…more
  • Overcoming the poor bioavailability of curcumin in the near future would facilitate its clinical use in treatment of cancer…more
  • UBS109 is efficacious in retarding the growth of Tu212 (head and neck) squamous cell carcinoma (SCC) xenograft tumors in mice and may be useful for treating head and neck SCC tumors…more
  • Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1…more

Treatment for Head & Neck Cancer

  • Prereferral head and neck cancer treatment: compliance with national comprehensive cancer network treatment guidelines….more
  • SEOM clinical guidelines for the treatment of head and neck cancer.more
  • Head and neck cancer in India: need to formulate uniform national treatment guideline?....more
  • Guidelines for treatment of recurrent or metastatic head and neck cancer...more
  • Current treatment options for metastatic head and neck cancer...more
  • Acupuncture for the prevention of radiation-induced xerostomia in patients with head and neck cancer...more
  • Curcumin Enhances the Effect of Cisplatin in Suppression of Head and Neck Squamous Cell Carcinoma via Inhibition of IKKβ Protein of the NFκB Pathway...more

Prevention of Head & Neck Cancer

  • Toenail selenium reduces the risk of head-neck cancer...more
  • Head and neck cancer: causes, prevention and treatment...more
  • Greater vitamin E intake from foods may lower HNC risk...more
  • Tea drinking may reduce the risk of HNC...more
  • Effective toothbrushing may be potentially important for the prevention of HNC...more

Risk factors for Head & Neck Cancer

  • HCV is associated with nonoropharyngeal (except nasopharyngeal) and HPV-positive oropharyngeal HNCs. Further studies are required to explore the possible interaction between HCV and HPV, and the association between HCV and other HPV-related malignancies...more
  • Launderers (OR = 6.8; CI, 1.3 to 34.4), firefighters (OR = 3.9; CI, 1.4 to 11.2), several agricultural occupations, welders (OR = 1.9; CI, 1.3 to 2.8), structural metal preparers and erectors (OR = 2.1; CI, 1.2 to 3.7), rubber workers (OR = 2.0; CI, 1.0 to 3.9) are at greater risk head and neck cancer...more
  • Diabetes is associated with an increased risk of developing HNC...more
  • Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk...more
  • Drinking >3 alcoholic beverages per day was associated with increased risk in men and women, but consumption of up to one drink per day may be associated with reduced risk of neck cancer….more
  • HPV may play a major role in the carcinogenesis of urogenital and nasopharyngeal tumors and the transmission potential of orogenital sex..more
  • Poor condition of the mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74, 4.81; Latin America: OR = 1.89, 95% CI: 1.47, 2.42), lack of toothbrush use (Latin America: OR = 2.36, 95% CI: 1.28, 4.36), and daily mouthwash use (Latin America: OR = 3.40, 95% CI: 1.96, 5.89) emerged as risk factors for head and neck cancer..more

Systematic reviews

  • A systematic review of interventions for eating and drinking problems following treatment for head and neck cancer suggests a need to look beyond swallowing and trismus...more
  • Systematic review and meta-analysis of radiotherapy in various head and neck cancers...more
  • A systematic review of patient-reported outcome measures in head and neck cancer surgery…more
  • Use of gastrostomy in head and neck cancer: a systematic review to identify areas for future research...more
  • Two-week rule in head and neck cancer 2000-14: a systematic review...more

Treatment with Medicinal Herbs

  • Chamomile (Matricaria recutita) – Dose – 1 tbsp fresh flower; 3-6 g dry flower; 4.5 g dry flower: 22 ml alcohol/23 ml water; 2-8 g flower; 2-8 g flower 3x/day 
  • Nettle (Urtica dioica) – Dose – 3-4 tsp (~4 g) shoot/cup water several x/day; 3-4 tsp (4-6 g) shoot or leaf in 150 ml boiling water cooled, 3-4 x/day; 9 g leaf /day for arthrosis 
  • Woodruff (Galium odoratum) – Dose – 2 tsp (1.8 g) shoots/glass water; 1 g drug/day 

Reference: Handbook of Medicinal Herbs (2006)


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