Hair Loss

Hair Loss

Hair loss

Facts about Hair Loss

  • Up to 40% of men in their thirties experience hereditary hair loss and by age 50, half of all men experience it.
  • Hereditary hair loss can come from the mother’s OR the father’s side of the family.
  • The average scalp is covered with 100,000 hair follicles.
  • No new follicles are formed after birth.
  • Most people lose between 50-100 hairs a day – but a consistent loss of 150 hairs or more a day is considered significant hair loss.

Research scope in Hair loss

  • Pharmacological targeting of histone deacetylases may afford a strategy for protection against noise-induced hearing loss (NIHL)….more
  • LL-37 increases EGR1 expression and MAPK activation, and that preconditioning of adipose-derived stromal/stem cells (ASCs) with LL-37 has a strong potential to promote hair growth in vivo.more
  • CD4 and cytotoxic CD8 T-cells (CTLs) are important for the onset and progression of AA. Hair follicle (HF) keratinocyte and/or melanocyte antigen epitopes are suspected potential targets of auto-reactive CTLs, but the specific epitopes have not yet been identified....more
  • Imiquimod may have the potential to improve prognosis in nonresponder AA patients treated with diphenylcyclopropenone (DCP)...more
  • Platelet-rich plasma (PRP) showed a positive effect on AGA and could be regarded as an adjuvant therapy for androgenetic alopecia (AGA)...more
  • A penta-peptide, Gly-Pro-Ile-Gly-Ser (GPIGS), promotes proliferation of mouse hair keratinocytes and accelerates hair growth in mice...more

Treatment for Hair Loss

  • Low-level laser treatment may be an effective option to treat pattern hair loss in both men and women….more
  • 5% minoxidil and 0.01% tretinoin once-daily therapy appear to be equivalent to those of conventional 5% minoxidil twice-daily therapy for the treatment of androgenetic alopecia (AGA).more
  • G. elliptica extract has the potential to treat alopecia via the proliferation of dermal papilla, 5α-reductase inhibition, increase of PGE2 production, decrease of LPS-stimulated pro-inflammatory cytokines and inhibitory activity against Pityrosporum ovale....more
  • Vitamin D3 analogs seem to act on keratinocytes to initiate hair follicle cycling and stimulate hair growth in mice that otherwise do not grow hair...more
  • Supplementation with tocotrienol capsules increases hair number in volunteers suffering from hair loss...more

Prevention of Hair Loss

  • Shampoo are useful in the prevention of hair loss...more
  • In conclusion, bee venom is a potentially potent 5α-reductase inhibitor and hair growth promoter...more
  • Polyphenol extract in their drinking water, had significant hair regrowth during six months of treatment (p = 0.014) in rodents...more
  • Scalp cooling can prevent chemotherapy-induced alopecia (CIA) in patients receiving chemotherapy...more

Risk factors for Hair Loss

  • Low iron store represents a risk factor for hair loss in non-menopausal women..more
  • Hair loss is common among patients with inflammatory bowel disease (IBD)...more
  • Oral contraceptive use (OR 1.21, 95% CI 1.01-1.45) and ultraviolet exposure more than 16 hours per week (OR 1.12, 95% CI 1.02-1.22) are associated with hair loss...more
  • The probability of male pattern hair loss is dependent on family history and age...more
  • Low serum ferritin and vitamin D2 are associated with hair loss in females....more

Systematic reviews

  • Evidence-based treatments for female pattern hair loss: a summary of a Cochrane systematic review...more
  • Hair removal policies in clean surgery: systematic review of randomized, controlled trials...more
  • Androgenetic alopecia and risk of prostate cancer: a systematic review and meta-analysis…more
  • Current Treatment Strategies in Pediatric Alopecia Areata...more
  • Efficacy of interventions for prevention of chemotherapy-induced alopecia: a systematic review and meta-analysis...more

Treatment with Medicinal Herbs

  • Bayberry (Morella cerifera) Dose – 0.6-2 g powered bark by infusion or decoction, 3 x/day; 20-30 grains powered bark; 1-4 g powered bark; 1.5 – 3 g dry bark; 2 g dry bark: 10 ml alcohol/10 ml water; 1-3 tbsp fresh bark
  • Black Bryony (Tamus comunis) Dose – Don’t take internally. Fruits steeped in gin for chilblain
  • Black Walnut (Juglans nigra) Dose – 10-20 drops fluid extract/day; 495 mg hull capsules 3x/day; 2-3 fresh fruit rind; 1-1.5 g dry fruit rind; 1 g dry fruit, 5 ml alcohol/5 ml water
  • Yarrow, Milfoil (Achillea millefolium) Dose – 1-2 tsp herb/cup water 3-4 x/day; 4.5 g herb; 2-4 tbsp fresh herb; 3-6 g dry herb; 2-4 ml liquid herb extract; 2-4 ml liquid herb extract (1:1 in 25% ethanol) 3x/day; 2-4 ml herb tincture (1:5 in 45% ethanol) 3x/day 

Reference: Handbook of Medicinal Herbs (2006)


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