Endometrial cancer

Endometrial cancer

Ovary

Facts about Endometrial Cancer

  • The American Cancer Society estimates for cancer of the uterus in the United States for 2016 are: About 60,050 new cases of cancer of the body of the uterus (uterine body or corpus) will be diagnosed. About 10,470 women will die from cancers of the uterine body.
  • In the United States, cervical cancer is the most common cancer to originate in the female reproductive organs.
  • Most cases occur between the ages of 60 and 70 years, but in rare instances, may develop before the age 40.

Research scope in Endometrial Cancer

  • Serum miR-887-5p levels were significantly increased in patients with endometrial cancer. Therefore, serum miR-887-5p could be used as a potential biomarker for endometrial cancer…..more
  • Polymorphisms in TGFB1, TGFBR1, SNAI1 and TWIST1 may modulate EC susceptibility, both separately and corporately…..more
  • The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. ...more
  • The potential role of Fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) (FDG-PET/CT) in other gynecologic malignancies such as endometrial cancer, uterine sarcomas, vaginal, and vulvar cancer has not been fully explored....more
  • The study suggest that ‘surface epithelial changes’ (SECs) are of neoplastic origin and that KRAS mutations play an important role in the tumorigenesis of endometrioid adenocarcinomas (ECs) and SECs….more
  • Cancers harboring polymerase epsilon (POLE) mutations are good candidates for immune checkpoint inhibitor therapy…..more
  • miR-99a as a potential biomarker and therapeutic target for endometrial carcinoma (EC)….more

Treatment for Endometrial Cancer

  • Oral progestin treatment is feasible and safe for patients of reproductive age.more
  • Bariatric surgery is associated with a reduced risk of endometrial cancer after the procedure. ..more
  • In patients with endometrial cancer, higher level of ER and PR predicted favorable survival, and increased level of HER2 was associated with poorer survival....more
  • Adjuvant Therapy in Early-Stage Endometrial Cancer: A Systematic Review of the Evidence, Guidelines, and Clinical Practice in the U.S....more
  • Lifestyle interventions have the potential to improve the QoL of endometrial cancer and ovarian cancer survivors, and may significantly reduce fatigue...more

Prevention of Endometrial Cancer

  • Regular use of aspirin or NA-NSAIDs was associated with a marginally reduced risk of endometrial cancer….more
  • Soy food intake is associated with lower endometrial cancer risk….more
  • Physical activity seems to be associated with a reduction in the risk of endometrial cancer, which is independent of body weight. ..more
  • Green tea, but not black tea, may be related to a reduction of endometrial cancer (EC) risk….more
  • Higher dosage or frequency of aspirin use was significantly associated with a reduced risk, and long-term aspirin use was protective only for obese women. ..more
  • Study provides evidence for a beneficial role of the Mediterranean diet on endometrial cancer risk, suggesting a favourable effect of a combination of foods rich in antioxidants, fibres, phytochemicals, and unsaturated fatty acids…..more

Risk factors for Endometrial Cancer

  • General obesity in adulthood, as well as body fat distribution, were associated with the risk of endometrial cancer independently. ..more
  • Nulliparity, obesity, unstable menstruation, smoking and cancer in the family are strongly correlated with endometrial cancer risk in women ≤40 years...more
  • The study says that ndometriosis may be a risk factor for endometrial or ovarian cancer in women between 40 and 85 years....more
  • High leptin level is an independent risk factor of endometrial cancer...more
  • Long-term recent use of estrogen-progestin combined replacement therapy may increase the risk of breast cancer...more
  • Women with a first-degree family history of endometrial cancer or colorectal cancer have a higher risk of developing endometrial cancer than those without a family history...more
  • Significantly higher risk of EC in women with high fasting insulin, non-fasting/fasting C-peptide and HOMA-IR values….more
  • Increased BMI is significantly associated with increased all-cause mortality in women with endometrial cancer, with the highest risk for those with a BMI≥40....more

Systematic reviews

  • Body mass index and the quality of life of endometrial cancer survivors–a systematic review and meta-analysis….more
  • All measures of adiposity were associated with increased risk of endometrial cancer..more
  • Compared with never use, ever use of oral contraceptives is significantly associated with decreases in colorectal and endometrial cancers and increases in breast cancers…more
  • Vaccines currently available are effective, safe and capable of preventing in cervical cancer prevention and CIN2+ lesions….more
  • Past, Present and Future Perspectives on the Management of Endometrial Cancer— A Comprehensive Review..more
  • Nut consumption may play a role in reducing cancer risk. ...more
  • Meta-analysis demonstrates that low level of circulating adiponectin is a risk factor for endometrial cancer. ...more

Treatment with Medicinal Herbs

  • Oakgall (Quercus infectoria Olivier) – Dose – 1 part gall: 5 parts wine
  • Opium poppy (Papaver somniferum) – Dose – 30-125 mg 
  • Tamarind (Tamarindus indica) – Dose – 1-3 g fruit pulp; 4-8 g fruit pulp/day; 4-30 g fruit pulp; 10-15 g tamarind paste; 1-2 g powdered seed

Reference: Handbook of Medicinal Herbs (2006)

Herbals

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