Facts about Depression

  • Globally, an estimated 350 million people of all ages suffer from depression
  • 80% of individuals affected by depression do not receive any treatment?
  • 1 in 4 young adults will suffer an episode of depression before age 24
  • Women experience depression about twice as often as men

Research scope in Depression

  • In spite of recent progress in the pharmacotherapy of depression major issues are still unresolved. These include the non-response rate of approximately 30% to conventional antidepressant pharmacotherapy…more 
  • NMDA receptor antagonists and magnesium have shown the ability to sprout new synaptic connections, opening up promising new territory for the development of drugs to treat depression…more
  • Therapeutic potential of targeting the immune system to treat depression…more
  • Despite intensive research during the past several decades, the neurobiological basis and pathophysiology of depressive disorders remain unknown…more

Treatment for Depression

  • Treatment of depression: time to consider folic acid and vitamin B12, more…
  • Cognitive therapy is as efficacious as antidepressant medications at treating depression, and it seems to reduce the risk of relapse even after its discontinuation, more…
  • Current guidelines for depression treatment, more…
  • Zinc supplementation significantly reduced depression score, more…
  • Practice guideline for the treatment of patients with major depressive disorder, more…


  • Depression as a risk factor for Alzheimer disease, more…
  • Vision function is greatly affected by depression, more…
  • Depression is a strong risk factor for incident unprovoked seizures, more…
  • Alcohol problems common in depression than in the general population, more…

Risk factors for Depression

  • Sleep disturbance risk factors for depression among elderly community subjects…more
  • Low folate status is associated with depression…more
  • High glycemic index diet can be a risk factor for depression…more
  • Loneliness is a specific risk factor for depressive symptoms…more
  • Magnesium deficiency is the cause of most major depression and related mental health problems including IQ loss…more
  • Life stress, lack of social support, and domestic violence demonstrate a significant association with depression…more

Systematic reviews

  • A Systematic Review of Comparative Efficacy of Treatments and Controls for Depression..more
  • A systematic review and meta-analysis of trials of treatment of depression from India...more
  • Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis…more
  • A systematic review of depression treatments in primary care for Latino adults…more
  • Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis...more

Treatment with Medicinal Herbs

  • Ginger (Zingiber officinale) – Dose 3-10 g fresh ginger, or 2-4 dry ginger, 1-3x/day; 0.3-1.5 g rhizome several x/day; 500-1000 mg fresh root 3x/day; 2-4 tbsp fresh root
  • Spanish Bayonet (Yucca filamentosa) –  Dose 3 (490) capsules 3x/day
  • Green or Black tea (Camellia sinensis)Dose 1-2 tsp dry leaf/cup water 1-3 x/day; 50-100 mg green tea ployphenols; 100-200 mg StX (50% polyphenols); three 333-mg tea capsules, each containing 50 mg polyphenols/day

Reference: Handbook of Medicinal Herbs (2006)


TR1Scientists discover 17 genetic variations that raise risk of depression

Scientists have discovered 17 separate genetic variations that increase the risk of a person developing depression.  The findings, which came from analyzing DNA data collected from more than 300,000 people, are the first genetics links to the disease found in people of European ancestry. The scientists say the research will contribute to a better understanding of the disease and could eventually lead to new treatments. They also hope it will reduce the stigma that can accompany depression. More at:

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