Asthma

Asthma

Asthma

Facts about Asthma

  • According to WHO estimates, 235 million people suffer from asthma.
  • Asthma is the most common chronic disease among children.
  • Asthma is not just a public health problem for high income countries: it occurs in all countries regardless of level of development. Over 80% of asthma deaths occurs in low and lower-middle income countries.
  • Asthma is under-diagnosed and under-treated, creating a substantial burden to individuals and families and possibly restricting individuals’ activities for a lifetime.

Research scope in Asthma

  • Excessive mucus causes severe airflow obstruction in fatal asthma. It is also present in mild to moderate disease, but is poorly understood and treated…more
  • The mechanisms by which Vit D influences airway structure and function in the context of inflammation and asthma remains undefined…more
  • The involvement of Grx1/S-glutathionylation in allergic inflammation induced by asthma-relevant allergens remains unknown…more
  • Asthma and allergic diseases are among the most prevalent chronic noncommunicable diseases of childhood, but the underlying pathogenetic mechanisms are poorly understood…more
  • Researchers are struggling to understand the mechanisms of disease that operate in Th2-low asthma…more
  • Macrophages (MPs) are one of the most prominent leukocyte populations in the lung and, in many ways, a forgotten player in asthma pathogenesis…more
  • Effectiveness of influenza vaccination in people with asthma against influenza-related complications is still not well established…more
  • Children with asthma have low vitamin D levels; however, we do not know whether low vitamin D is associated with impaired T-regulatory (Treg) cell population or high IgE receptors (CD23 and CD21) on B cells…more
  • It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency…more

Prevention of Asthma

  • Study indicates that exclusive breast-feeding prevents development of allergic diseases in children… more…
  • Breast-feeding reduces the risk of asthma during the first 4 years of life… more…
  • In children with Atopic dermatitis (AD), cat exposure may reduce the risk of developing early childhood asthma… more…
  • Breastfeeding is protective for asthma (5-18 years)… more…
  • These results suggest that ketotifen is effective in preventing the onset of asthma in preasthmatic children… more…
  • Physical activity could cause some changes in the pulmonary volumes and capacities as well as sleep quality levels, so that could be helpful in prevention of asthma… more…
  • Lactobacillus casei rhamnosus Lcr35 could inhibit airway inflammation and may have potential for preventing asthma… more…

Treatment for Asthma

  • Advances in adult asthma diagnosis and treatment in 2014… more…
  • Global guidelines for asthma management: summary of the current status and future challenges… more
  • Current guidelines for the management of asthma in young children… more…
  • Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis… more…
  • Montelukast for prevention and treatment of asthma exacerbations in adults: Systematic review and meta-analysis… more
  • Intravenous magnesium sulphate for treating acute asthma… more…
  • Macrolide antibiotics are useful for treatment of asthma in adults… more
  • Asthmatic children who received L-carnitine supplementation showed statistically significant improvement… more…

Risk factors for Asthma

  • This study revealed that exposure to indoor (tobacco smoke, coal stove emission, mould or dampness in dwelling) and outdoor (traffic pollution) air contaminants are major environmental factors responsible for adverse respiratory health effects in children…more
  • Childhood asthma was strongly associated with a family history of asthma and allergic rhinitis…more
  • The results show that maternal asthma increases offspring disease risk to a greater extent than paternal disease…more
  • Anemic children were 5.75 times more susceptible to asthmatic attacks when compared with nonanemic children…more
  • Being overweight is associated with an increased risk of new-onset asthma in boys and in nonallergic children…more
  • Frequent intake of paracetamol is an independent risk factor for adult-onset asthma…more
  • Reduced lung function at birth is associated with an increased risk of asthma by 10 years of age…more

Systematic reviews

  • Herbal treatments of asthma: a systematic review….more
  • Relaxation therapies for asthma: a systematic review…more
  • Economic burden of asthma: a systematic review…more
  • Breastfeeding and childhood asthma: systematic review and meta-analysis…more
  • Weight loss and asthma: a systematic review…more

Treatment with Medicinal Herbs

  • Air Potato (Dioscorea bulbifera)Dose – 6-12 g powdered tuber
  • Celery (Apium graveolens)Dose – 200 g root boiled in 500 g water taking 1 cup every 3 hours as antigalactic; 1-2 leaves for colic; 1-4 g powered seed; 1-2 tsp seed/cup water; 1-2 g dry seed; 2 g dry seed: 10 ml alcohol/10 ml water
  • Levant cotton (Gossypium herbaceum)Dose – 100 g root 1 litre water, reduced by boiling to 0.5 litre, take 50 g liquid every half hour (dangerous formula for abortion); 1-2 tbsp fluid extract during childbirth
Herbals

HN1New drug for severe asthma ‘shows massive promise’

“Asthma drug ‘gamechanger’ could revolutionise treatment,” The Guardian reports after a new drug called fevipiprant showed promising results in a small study of 61 people with moderate to severe asthma. Asthma is an autoimmune condition, which means the immune system – the body’s defence against infections – malfunctions and attacks healthy tissue. It can cause inflammation of the airways, which can lead to breathing difficulties. More at:http://www.nhs.uk/news

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