Alzheimer’s Disease!

Alzheimer’s disease

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Facts about Alzheimer

  • Alzheimer’s disease (AD) is the most common neurodegenerative disorder.
  • Worldwide prevalence of the disease is estimated at more than 24 million cases.
  • The annual incidence worldwide is estimated at 4.6 million cases which is the equivalent of one new case every seven seconds!

Research scope in Alzheimer’s Disease

  • PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease…more 
  • The SNPs rs302668 in RAB38, rs9268877 and rs9268856 polymorphism in HLA-DRA/HLA-DRB5, and rs1980493 polymorphism in BTNL2 might play a role in Alzheimer’s Disease…more
  • There is a paucity of research that aims to identify specific underlying neural mechanisms associated with music’s beneficial effects in Alzheimer’s Disease…more
  • Better understanding of association of vascular/cerebrovascular health with clinical and pathological Alzheimer’s disease may inform prevention and treatment opportunities…more

Prevention of Alzheimer

  • Physical activity (PA) is neuroprotective and reduces the risk for Alzheimer’s disease (AD), more…
  • Dietary coconut udeful for the prevention and treatment of Alzheimer’s disease, more…
  • Higher education is protective from Alzheimer disease, more…
  • Use of nonsteroidal anti-inflammatory drugs, wine consumption, coffee consumption, and regular physical activity were associated with a reduced risk of Alzheimer’s disease, more…

Treatment for Alzheimer

  • Currently available treatments for AD (donepezil, rivastigmine, galantamine and memantine) are symptomatic and do not decelerate or prevent the progression of the disease, more…
  • Medications for the treatment of Alzheimer’s disease, more
  • NICE UK guidelines for the treatment of Alzheimer’s disease, more…

Risk factors for Alzheimer

  • Chronic aluminum intake causes Alzheimer’s disease…more
  • A history of migraines increased the risk of Alzheimer’s disease…more
  • The risk of Alzheimer’s increased with the number of risk factors (diabetes + hypertension + heart disease + current smoking)…more
  • Head trauma is a risk factor for Alzheimer’s disease…more
  • Herpes simplex virus type 1 (HSV1) as a strong risk factor for Alzheimer’s disease when it is present in brain of carriers of the type 4 allele of the gene for apolipoprotein E (APOE-4)…more

Systematic reviews

  • Ginkgo biloba in Alzheimer’s disease: a systematic review...more
  • Pharmacological treatment of neuropsychiatric symptoms in Alzheimer’s disease: a systematic review and meta-analysis...more
  • Acupuncture for Alzheimer’s disease: a systematic review...more
  • Lithium as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis...more
  • Systematic review of atorvastatin for the treatment of Alzheimer’s disease...more

Treatment with Medicinal Herbs

  • Grape seed (Vitis vinifera) – Dose 75-600 mg seed extract (or pycnogenol)/day for up to 3 weeks; maintenance dose – 40-100 mg/day
  • Amur Corktree (Phellodendron amurense) – Dose 3-10 g powered bark/day; 1-3 g bark/day; 1-3 g 4:1 dry decoction
  • Basil, Sweet Basil (Ocimum basilicum) – Dose 1-2 tsp herb/cup water 2-3 x/day; 0.5-1 tsp tincture up to 3 x/day; 5 g leaf/200 cc water for gas; 20 g leaf/300 cc water for aphtha; 15 fresh plant/L water, one cup before retiring
  • Clove (Syzygium aromaticum) – Dose 120-320 mg clove; 100-300 powdered clove; 0.05-0.2 ml clove oil 

Reference: Handbook of Medicinal Herbs (2006)

Herbals

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