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- Here is the list of foods found to be linked to type 2-diabetes.
- Down syndrome, also known as trisomy 21, is a genetic disorder which is caused by defects in the chromosome 21. It is typically associated with physical and mental health delays. IQ of an individual with this disease is equivalent to an 8-9 years old child.
Epidemiology and burden of Down Syndrome
- Incidence of Down syndrome is between 1 in 1,000 live births worldwide. Every year approximately 3,000 to 5,000 children are born with this disorder. (http://www.who.int/genomics/public/geneticdiseases)
- Every year between 23,000 and 29,000 children are born in India with Down syndrome, which is the highest in the world. (http://www.deccanherald.com/content)
- The study concluded that recombinant human growth hormone therapy can result in a significant increase in annual growth rate and head circumference in children with Down syndrome, without significant side effects (J Pediatr.1991 Sep;119(3):478-83).
- Medications for treatment of Alzheimer’s disease may also result in benefit for the population of individuals with Down syndrome. (Ment Retard Dev Disabil Res Rev.2005;11(2):149-55)
- The study demonstrated that there is a greater prevalence of obesity amongst women with Down syndrome but not men. (J Intellect Disabil Res.2005 Feb;49(Pt 2):125-33)
- A case-control study showed that Down syndrome patients display more severe periodontal destruction earlier (inflammation of the tissues that surround and support the teeth), and heavier colonization with periodontal pathogens. (J Clin Periodontol.2005 Jun;32(6):684-90)
- Meta-analysis suggests an association of the MTHFR C677T polymorphism with maternal risk for Down syndrome (DS). Moreover, no association between the MTHFR A1298C polymorphism and maternal risk for DS was found. (Mol Biol Rep.2014 Aug;41(8):5491-504)
- A study showed that intracardiac echogenic foci (a small bright spot seen in the baby’s heart on an ultrasound exam) increase the risk of Down syndrome five- to seven-fold. (Obstet Gynecol.2003 May;101(5 Pt 1):1009-16)
- Two kinds of common prenatal screening tests for Down’s syndrome: a systematic review and meta-analysis…more
- Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome — meta-analysis…more
- Folate Metabolism and Genetic Variant in Down Syndrome: A Meta-Analysis…more
- Dental caries in individuals with Down syndrome: a systematic review…more
- Alzheimer’s Disease in Down Syndrome-meta-analysis…more